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ML domain The MD-2-related lipid-recognition (ML) domain is implicated in lipid recognition, particularly in the recognition of pathogen related products. It has an immunoglobulin-like beta-sandwich fold similar to that of immunoglobulin E-set domains. This domain is present in the following proteins: * Epididymal secretory protein E1 (also known as Niemann-Pick C2 protein), which is known to bind cholesterol. Niemann-Pick disease type C2 is a fatal hereditary disease characterised by accumulation of low-density lipoprotein-derived cholesterol in lysosomes. * House dust mite allergen proteins such as Der f 2 from ''Dermatophagoides farinae'' and Der p 2 from ''Dermatophagoides pteronyssinus''. ==Human proteins containing this domain == LY86; LY96; MMD-1;
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「ML domain」の詳細全文を読む
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